Diuretic Activity of the Aqueous Extract Leaves of Ficus glumosa Del. (Moraceae) in Rats

Table 5

Effects of the aqueous extract of F. glumosa on index kidney function.

Drugs (mg/kg)	Control	225 mg/kg	300 mg/kg	375 mg/kg	Furosemide (2 mg/kg)	Amiloride H. (14 mg/kg)
Creatinine (mg/24 h)	24.66 ± 4.93	17.66 ± 1.52***	21 ± 2.64**	25.00 ± 3.60*	20.00 ± 4.35**	26.33 ± 5.50
CreatC (mL/min)	0.027 ± 0.02	0.024 ± 0.06*	0.021 ± 0.04**	0.019 ± 0.03***	0.020 ± 0.02**	0.019 ± 0.04***
Urea (g/24 h)	26.33 ± 3.21	22.33 ± 1.52***	23.00 ± 4.35*	25.66 ± 4.72	23.66 ± 1.52**	21.33 ± 1.52***
Uosm (mosmol/kg)	199 ± 17	109 ± 18***	111 ± 13***	121 ± 17***	169 ± 28***	157 ± 12***
GFR (mL/min)	1.60 ± 0.51	1.53 ± 0.32*	1.50 ± 0.12*	1.40 ± 0.14**	1.35 ± 0.17***	1.30 ± 0.22***
Cosm (mL/min)	0.046 ± 0.005	0.044 ± 0.011	0.045 ± 0.015	0.047 ± 0.007**	0.075 ± 0.011***	0.065 ± 0.009***
. (mL/min)	0.055 ± 0.011	0.053 ± 0.014	0.055 ± 0.021	0.065 ± 0.006***	0.067 ± 0.012***	0.065 ± 0.014***

Values are means ± SEM, , , , , significant difference compared to the control.
CreatC: creatinine clearance; Uosm: urinary osmolarity;
GFR: glomerular filtration rate; Cosm: osmolar clearance;
: free water clearance.