Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients
Table 2
SPM results of the difference in FDG metabolism between groups.
Comparison groups
Cluster size
Voxel level
Anatomic locations
value
score
MNI coordinates (, , )
MET > noMET
421
4.58
3.77
48, −22, −10
Right temporal lobe, subgyral white matter
3.38
2.99
42, −44, −14
401
4.70
3.84
−40, −68, 0
Left occipital lobe, subgyral white matter
4.51
3.73
−34, −54, −6
Left temporal lobe, subgyral white matter
683
3.87
3.32
30, 14, 40
Right frontal lobe, subgyral white matter
3.84
3.31
18, 10, 38
Right limbic lobe, white matter
3.84
3.30
20, −2, 46
MET < noMET
217
4.35
3.63
−24, −32, −14
Left limbic lobe, parahippocampal gyrus
160
4.20
3.54
−48, −44, −26
Left temporal lobe, fusiform gyrus (BA 37)
623
4.94
3.98
10, 56, −22
Right frontal lobe, orbital gyrus (BA 11)
4.00
3.41
−8, 34, −26
Left frontal lobe, rectal gyrus (BA 11)
3.16
2.83
10, 28, −20
Right frontal lobe, medial frontal gyrus (BA 25)
wdMET > noMET
230
4.99
3.82
50, −26, −12
Right temporal lobe, subgyral white matter
237
3.89
3.21
−40, −62, −4
Left occipital lobe, subgyral white matter
3.05
3.11
−34, −74, −2
3.73
3.11
−38, −54, −2
Left temporal lobe, subgyral white matter
249
4.22
3.41
20, 2, 46
Right frontal lobe, subgyral white matter
3.27
2.82
18, −18, 48
wdMET < noMET
175
5.26
3.95
−30, −34, −22
Left limbic lobe, parahippocampal gyrus
MET > wdMET
340
4.07
3.53
28, 14, −14
Right frontal lobe, subgyral white matter
MET < wdMET
—
—
—
—
No suprathreshold cluster
Threshold at , uncorrected, voxels. MET: patients taking metformin; wdMET: patients withdrawing from metformin for more than 3 days; noMET: patients not taking metformin; BA: Brodmann area.
