Multiparametric Monitoring of Early Response to Antiangiogenic Therapy: A Sequential Perfusion CT and PET/CT Study in a Rabbit VX2 Tumor Model
Table 1
Perfusion and metabolic parameters between the treatment and the control groups at each time point.
Parameters
Before
3 D
7 D
14 D
Treatment
Control
Treatment
Control
Treatment
Control
Treatment
Control
Tumor volume (cm3)
0.18 ± 0.08
0.18 ± 0.10
0.53 ± 0.32
0.43 ± 0.23
0.79 ± 0.47
0.76 ± 0.57
1.53 ± 1.11
1.88 ± 1.32
Blood flow (mL/100 mL/min)
36.16 ± 11.15
28.64 ± 13.78
35.82 ± 25.93
36.44 ± 9.22
30.05 ± 14.87
54.13 ± 30.11
34.34 ± 17.10
70.75 ± 50.65
Blood volume (mL/100 mL)
25.36 ± 5.62
22.56 ± 5.56
16.71 ± 4.91
22.81 ± 5.95
19.99 ± 5.30
23.54 ± 9.04
18.35 ± 7.48
32.20 ± 9.76
PS (mL/100 mL/min)
9.47 ± 3.09
11.18 ± 2.24
10.18 ± 5.81
9.39 ± 1.58
7.246 ± 1.97
12.06 ± 7.25
7.36 ± 2.48
9.91 ± 3.59
SUVmax
1.45 ± 0.26
1.31 ± 0.43
2.23 ± 0.65
2.21 ± 0.60
2.42 ± 0.92
2.13 ± 0.89
3.03 ± 1.36
3.73 ± 1.22
SUVmean
0.96 ± 0.18
0.84 ± 0.29
1.30 ± 0.33
1.33 ± 0.29
1.33 ± 0.40
1.27 ± 0.45
1.77 ± 0.66
2.10 ± 0.54
TLG (cm3)
0.43 ± 0.22
0.35 ± 0.16
1.16 ± 0.63
1.20 ± 0.55
1.96 ± 1.28
1.61 ± 1.13
4.43 ± 3.63
4.78 ± 3.95
Entropy
5.95 ± 0.32
5.80 ± 0.47
6.36 ± 0.34
6.41 ± 0.35
6.58 ± 0.32
6.46 ± 0.46
6.69 ± 0.57
6.91 ± 0.34
Homogeneity
0.31 ± 0.07
0.26 ± 0.10
0.32 ± 0.06
0.30 ± 0.05
0.34 ± 0.04
0.32 ± 0.06
0.34 ± 0.05
0.33 ± 0.05
FMR
27.10 ± 12.19
25.19 ± 20.54
17.12 ± 12.80
17.33 ± 7.20
13.55 ± 6.41
29.75 ± 22.78
12.24 ± 6.92
25.87 ± 29.22
Data are presented as mean ± standard deviation. Boldface indicates significant difference between the treatment and the control groups. PS: permeability surface area product. SUV: standardized uptake value. TLG: total lesion glycolysis. FMR: flow-metabolic ratio.
