Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents

Table 1

Physical data of synthesized benzamide substituted Mannich bases.

Compound	Color	Solubility	𝜆max	𝑅𝑓 value^#	% age yield	Molecular weight
1	Light brown crystals	DMSO, EtOH, CHCl3	226	0.45	84	220.273
2	Dark brown crystals	DMSO, EtOH, CHCl3	324	0.61	78.2	219.288
3	Light orange crystals	DMSO, EtOH, CHCl3	227	0.78	76	305.176
4	Light brown crystals	DMSO, EtOH, CHCl3	275	0.71	70.8	226.279
5	Colorless crystals	DMSO, EtOH, CHCl3	253	0.65	91.6	302.378
6	Yellow crystals	DMSO, EtOH, CHCl3	371	0.82	75	271.277
7	Yellow crystals	DMSO, EtOH, CHCl3	346	0.73	80	316.275

 ^#Stationary phase: silica gel. Mobile phase for TLC: petroleum ether : ethyl acetate : methanol (6 : 3 : 1). Iodine vapors as visualizing agent.