Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis
Figure 5
After an injury in the vessel wall, activation of platelets begins to start. It involves its adhesion to the subendothelium surface. Interaction between receptors like GPIb-V-IX, GPIa-IIa, and subendothelial compounds like vWf and collagen triggers the release of platelet granule contents accelerating aggregate formation.