Blocked Autophagy by miR-101 Enhances Osteosarcoma Cell Chemosensitivity In Vitro

Figure 1

Dox promotes autophagic vesicles formation in U-2 OS cells. (a) Autophagic vesicles formation in negative control U-2 OS cells; (b) autophagic vesicles formation in U-2 OS cells which were treated with 100 nM rapamycin (positive control); (c) and (d) autophagic vesicles formation in Dox-treated U-2 OS cells (0.1 μg/mL (c) or 0.2 μg/mL (d)). Statistical significance shown as ^∗𝑃<0.05, ^∗∗𝑃<0.01. All experiments were independently performed at least for three times.

(a)

(b)

(c)

(d)

(e)