HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China
Table 1
Baseline characteristics of the study patients and their tumors, according to tumor HPV status.
Characteristics
Total () no. (%)
HPV-positive () no. (%)
HPV-negative () no. (%)
value
Gender
Male
84 (80.0)
24 (82.8)
60 (78.9)
0.66
Female
21 (20.0)
5 (17.2)
16 (21.1)
Age
Median (range)
60 (42–78)
60 (44–75)
62 (42–78)
0.22△
Tumor location
Cervical/upper
11 (10.5)
6 (20.7)
5 (6.6)
0.07
Middle
49 (46.7)
14 (48.3)
35 (46.1)
Low
45 (42.9)
9 (31.0)
36 (47.4)
pT status
pT1
20 (19.0)
7 (24.1)
13 (17.1)
0.18☆
pT2
22 (21.0)
7 (24.1)
15 (19.7)
pT3
58 (55.2)
15 (51.8)
43 (56.6)
pT4
5 (4.8)
0 (0.0)
5 (6.6)
pN status
pN0
68 (64.8)
21 (72.4)
47 (61.8)
0.27☆
pN1
25 (23.8)
6 (20.7)
19 (25.0)
pN2
10 (9.5)
2 (6.9)
8 (10.5)
pN3
2 (1.9)
0 (0.0)
2 (2.6)
TNM stage (AJCC)
I
23 (21.9)
7 (24.1)
16 (21.1)
0.14
II
49 (46.7)
17 (58.6)
32 (42.1)
III
33 (31.4)
5 (17.2)
28 (36.8)
Differentiation grade
Well
27 (25.7)
11 (37.9)
16 (21.1)
0.21
Moderate
44 (41.9)
10 (34.5)
34 (44.7)
Poor
34 (32.4)
8 (27.6)
26 (34.2)
Adjuvant therapy
No
61 (58.1)
15 (51.7)
46 (60.5)
0.41
yes
44 (41.9)
14 (48.3)
30 (39.5)
Pack-years of smoking※
<20
42 (40.0)
15 (51.7)
27 (35.5)
0.13
≥20
63 (60.0)
14 (48.3)
49 (64.5)
Alcohol intake (kg/day)
<20
53 (50.5)
14 (48.3)
39 (51.3)
0.78
≥20
52 (49.5)
15 (51.7)
37 (48.7)
AJCC: American Joint Commission on Cancer Staging; Pt: pathological tumor stage; pN: pathological node stage. ☆P values were calculated with the use of the Kruskal-Wallis test. △P values were calculated with the use of the Mann-Whitney test. ※A pack-year is defined as the equivalent of smoking one pack of cigarettes per day for 1 year.
