HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China

Table 2

Correlation between HPV in situ hybridization and p16 immunohistochemistry in esophageal squamous cell carcinoma.

p16 status	Total; (𝑁=105); no. (%)	HPV-positive; (𝑁=29); no. (%)	HPV-negative; (𝑁=76); no. (%)	𝑃 value	Kappa value
Positive	39 (37.1)	25 (86.2)	14 (18.4)	<0.001	0.61
Negative	66 (62.9)	4 (13.8)	62 (81.6)

𝑃 and Kappa values were calculated with the use of Pearson’s chi-square test and Cohen Kappa test, respectively.