Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability Using ^𝟗𝟗𝐦𝐓𝐜-TRODAT-1 SPECT

Table 1

Pearson product-moment correlation coefficients (bottom left) and ratios of the root-mean-square differences to the averages (top right) between quantification methods of measuring DAT availabilities.

Method	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
(1) MRI-delineation	—	57%	33%	35%	30%	26%	21%	17%	15%	16%	43%	31%	23%	25%	30%	17%	19%	17%
(2) SPECT-delineation	0.56	—	32%	83%	79%	75%	70%	65%	59%	53%	32%	40%	61%	59%	35%	48%	70%	67%
(3) Template-ROI	0.79	0.65	—	62%	57%	52%	47%	42%	36%	30%	23%	23%	40%	38%	14%	23%	46%	43%
(4) 90% Threshold-ROI	0.74	0.50	0.70	—	5%	11%	17%	23%	30%	37%	71%	59%	40%	43%	59%	44%	21%	24%
(5) 85% Threshold-ROI	0.74	0.50	0.70	1.00	—	6%	11%	18%	25%	32%	66%	54%	36%	39%	54%	39%	17%	19%
(6) 80% Threshold-ROI	0.74	0.50	0.71	1.00	1.00	—	6%	12%	19%	26%	61%	50%	32%	35%	49%	34%	13%	15%
(7) 75% Threshold-ROI	0.74	0.51	0.71	1.00	1.00	1.00	—	6%	13%	21%	56%	45%	28%	31%	44%	29%	12%	12%
(8) 70% Threshold-ROI	0.75	0.51	0.72	1.00	1.00	1.00	1.00	—	7%	14%	51%	39%	25%	28%	38%	23%	13%	12%
(9) 65% Threshold-ROI	0.75	0.51	0.72	1.00	1.00	1.00	1.00	1.00	—	7%	45%	34%	24%	25%	31%	18%	17%	15%
(10) 60% Threshold-ROI	0.76	0.52	0.73	1.00	1.00	1.00	1.00	1.00	1.00	—	38%	28%	24%	25%	25%	13%	23%	20%
(11) MRI-normalization	0.78	0.55	0.70	0.74	0.74	0.74	0.74	0.75	0.75	0.75	—	14%	39%	36%	18%	31%	55%	51%
(12) MRI-norm., VC	0.78	0.55	0.70	0.73	0.73	0.73	0.74	0.74	0.75	0.75	1.00	—	26%	23%	15%	21%	43%	39%
(13) MRI-norm., GTM	0.75	0.52	0.68	0.71	0.71	0.71	0.71	0.72	0.73	0.73	0.99	0.99	—	4%	34%	23%	25%	23%
(14) MRI-norm., RBV	0.74	0.51	0.67	0.71	0.71	0.71	0.71	0.72	0.73	0.73	0.99	0.99	1.00	—	32%	22%	28%	26%
(15) SPECT-norm.	0.83	0.54	0.76	0.85	0.85	0.85	0.85	0.86	0.86	0.87	0.91	0.91	0.89	0.88	—	16%	42%	38%
(16) SPECT-norm., VC	0.82	0.52	0.75	0.85	0.85	0.85	0.85	0.86	0.86	0.87	0.88	0.88	0.86	0.86	1.00	—	26%	23%
(17) SPECT-norm., GTM	0.80	0.47	0.74	0.84	0.84	0.84	0.84	0.85	0.85	0.85	0.84	0.85	0.83	0.82	0.98	0.99	—	4%
(18) SPECT-norm., RBV	0.80	0.47	0.73	0.84	0.85	0.85	0.85	0.86	0.86	0.86	0.86	0.86	0.85	0.84	0.98	0.99	1.00	—

DAT: dopamine transporter; MRI: magnetic resonance imaging; SPECT: single photon emission-computed tomography; ROI: region of interest; norm.: normalization; GTM: geometric transfer matrix; RBV: region-based voxel-wise; VC: Van-Cittert deconvolution.