Research Article

4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells

Figure 2

4-HNE activates caspase-3 in MG63 cells. Western blots (a) and histograms (b) showing the increasing of protein levels of cleaved caspase-3 by 4-HNE treatment (5 to 50 μM, and 2 h to 4 h) in MG63 cells. Results are averages of three independent experiments.
873525.fig.002a
(a)
873525.fig.002b
(b)