Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent

Table 3

Docking result of fluoroquinolones analogue.

Sr. number	Title	Docking -score	Glide energy	Glide Emodel	XP H-bond	XP LipophilicEvdW	XP Electro
1	8g	−8.51	−54.3846	−105.214	−2.68	−4.84	−0.99
2	8i	−8.23	−72.1348	−119.918	−1.09	−6.14	−1.01
3	8e	−8.22	−70.9957	−98.0172	−1.95	−4.99	−1.27
4	8c	−7.95	−73.5718	−104.847	−1.83	−4.96	−1.16
5	8s	−7.83	−69.62	−117.139	−1.89	−5.67	−1.27
6	8q	−7.68	−63.5086	−106.854	−2.3	−4.98	−1.4
7	8h	−7.56	−74.8308	−102.867	−2.27	−4.06	−1.23
8	8n	−7.53	−65.1719	−95.4165	−0.68	−5.69	−1.16
9	8a	−7.43	−57.3206	−84.8511	−2.16	−5.19	−1.08
10	8b	−7.26	−69.2937	−97.1236	−2.11	−4.74	−1.41
11	8r	−7.26	−65.4352	−109.856	−0.81	−4.92	−1.54
12	8p	−6.84	−62.2759	−99.8452	−0.68	−3.76	−2.4
13	8j	−6.4	−69.2569	−108.236	−1.76	−4.42	−1.21
14	8f	−6.39	−69.32	−107.169	−0.64	−6.27	−0.49
15	8k	−6.31	−67.8452	−108.441	−0.04	−6.28	0.02
16	8l	−5.79	−68.5566	−97.1257	−0.80	−5.44	−0.35
17	8t	−5.57	−67.2658	−102.789	−0.64	−4.75	−1.18
18	8m	−5.11	−55.2368	−103.655	−0.81	−4.15	−1.15
19	8d	−3.86	−62.1285	−105.235	−0.8	−5.85	−1.21
20	8o	−3.63	−69.23	−110.249	−2.01	−4.56	−1.07
Standards were taken
Norfloxacin		−7.29	−54.2302	−83.0725	−1.68	−4.14	−1.04