Research Article
Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma
Table 2
Association of MMP13 protein expression with clinicopathological parameters.
| | Variables | Category | Number of patients (%) | MMP13 expression (, %) | value | | Low level of expression | High level of expression |
| | | | 103 | 21 (20.4) | 82 (79.6) | |
| | Total | | | | | |
| | Gender | Male | 35 (34.0) | 10 (28.6) | 25 (71.4) | 0.139 | | Female | 68 (66.0) | 11 (16.2) | 57 (83.8) |
| | Age (years) | 45 | 11 (10.7) | 3 (27.3) | 8 (72.7) | 0.691 | | 45 | 92 (89.3) | 18 (19.6) | 74 (80.4) |
| | Smoking | No | 81 (78.6) | 15 (18.5) | 66 (81.5) | 0.380 | | Yes | 22 (21.4) | 6 (27.3) | 16 (72.7) |
| | Drinking | No | 71 (68.9) | 13 (18.3) | 58 (81.7) | 0.435 | | Yes | 32 (31.1) | 8 (25.0) | 24 (75.0) |
| | Betel quid chewing | No | 49 (47.6) | 10 (20.4) | 39 (79.6) | 0.996 | | Yes | 54 (52.4) | 11 (20.4) | 43 (79.6) |
| | Tumor site | Non-tongue* | 68 (66.0) | 14 (20.6) | 54 (79.4) | 0.944 | | Tongue | 35 (34.0) | 7 (20.0) | 28 (80.0) |
| | Tumor size** | T1-T2 | 59 (58.4) | 16 (27.1) | 43 (72.9) | 0.063 | | T3-T4 | 42 (41.6) | 5 (11.9) | 37 (88.1) |
| | Lymph node metastasis** | Negative | 57 (56.4) | 17 (29.8) | 10 (70.2) | 0.011 | | Positive | 44 (43.6) | 4 (9.1) | 40 (90.9) |
| | pTNM staging** | Early stage | 38 (37.6) | 14 (36.8) | 24 (63.2) | 0.002 | | Advanced stage | 63 (62.4) | 7 (11.1) | 56 (88.9) |
| | Pattern of invasion** | Cohesive | 13 (15.5) | 5 (38.5) | 8 (61.5) | 0.140 | | Non-cohesive | 71 (84.5) | 13 (18.3) | 58 (81.7) |
| | Differentiation** | Well | 45 (44.1) | 11 (24.4) | 34 (75.6) | 0.392 | | Poor and Moderate | 57 (55.9) | 10 (17.5) | 47 (82.5) |
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Buccal mucosa, gingiva, lip, floor of mouth, palate.
**Data missing.
Significant values were highlighted in bold.
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