Research Article
Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma
Table 3
Multivariate cox regression model analysis of MMP13 mRNA expression in OSCC overall survival.
| Variables | Category | Number of patients (%) | Multivariate Logistic regression** | OR | 95% CI | value |
| Total | | 68 | | | |
| mRNA expression of MMP13 | Low | 50 (73.5) | 1.00† | 1.015–4.896 | 0.046 | High | 18 (26.5) | 2.23 |
| Gender | Male | 24 (35.3) | 1.00† | 0.388–2.806 | 0.933 | Female | 44 (64.7) | 1.043 |
| Age (years) | 45 | 12 (17.6) | 1.00† | 0.397–3.009 | 0.864 | 45 | 56 (82.4) | 1.092 |
| Smoking | No | 44 (64.7) | 1.00† | 0.240–2.071 | 0.524 | Yes | 24 (35.3) | 0.704 |
| Drinking | No | 51 (75.0) | 1.00† | 0.391–2.341 | 0.922 | Yes | 17 (25.0) | 0.956 |
| Betel quid chewing | No | 40 (58.8) | 1.00† | 0.652–3.718 | 0.319 | Yes | 28 (41.2) | 1.557 |
| Tumor site | Non-tongue* | 38 (55.9) | 1.00† | 0.516–2.933 | 0.640 | Tongue | 30 (44.1) | 1.230 |
| Lymph node metastasis | Negative | 33 (48.5) | 1.00† | 1.028–20.275 | 0.046 | Positive | 35 (51.5) | 4.565 |
| pTNM Staging | Early | 22 (32.4) | 1.00† | 0.339–13.469 | 0.419 | Advanced | 46 (67.6) | 2.137 |
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CI: confidence interval.
*Buccal mucosa, gingiva, lip, floor of mouth, palate. †Reference category. Significant values were highlighted in bold.
**Multivariate logistic regression analysis was applied to adjust the confounders age, gender, risk habits (cigarette smoking, betel quid chewing, and alcohol drinking), and clinicopathologic parameters tumor sites, lymph node metastasis, and pathological tumor staging.
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