Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma

Table 3

Multivariate cox regression model analysis of MMP13 mRNA expression in OSCC overall survival.

Variables	Category	Number of patients (%)	Multivariate Logistic regression**
			OR	95% CI	value
Total		68
mRNA expression of MMP13	Low	50 (73.5)	1.00^†	1.015–4.896	0.046
	High	18 (26.5)	2.23
Gender	Male	24 (35.3)	1.00^†	0.388–2.806	0.933
	Female	44 (64.7)	1.043
Age (years)	45	12 (17.6)	1.00^†	0.397–3.009	0.864
	45	56 (82.4)	1.092
Smoking	No	44 (64.7)	1.00^†	0.240–2.071	0.524
	Yes	24 (35.3)	0.704
Drinking	No	51 (75.0)	1.00^†	0.391–2.341	0.922
	Yes	17 (25.0)	0.956
Betel quid chewing	No	40 (58.8)	1.00^†	0.652–3.718	0.319
	Yes	28 (41.2)	1.557
Tumor site	Non-tongue*	38 (55.9)	1.00^†	0.516–2.933	0.640
	Tongue	30 (44.1)	1.230
Lymph node metastasis	Negative	33 (48.5)	1.00^†	1.028–20.275	0.046
	Positive	35 (51.5)	4.565
pTNM Staging	Early	22 (32.4)	1.00^†	0.339–13.469	0.419
	Advanced	46 (67.6)	2.137

CI: confidence interval.
*Buccal mucosa, gingiva, lip, floor of mouth, palate.
^†Reference category.
Significant values were highlighted in bold.
**Multivariate logistic regression analysis was applied to adjust the confounders age, gender, risk habits (cigarette smoking, betel quid chewing, and alcohol drinking), and clinicopathologic parameters tumor sites, lymph node metastasis, and pathological tumor staging.