Research Article
Nonlinear Quantitative Radiation Sensitivity Prediction Model Based on NCI-60 Cancer Cell Lines
Table 1
Univariate Cox regression analysis for three types of cancera.
| | Glioma (GSE4271 dataset) | Colon cancer (GSE17537 dataset) | Ovarian cancer (GSE9891 dataset) | | Gene symbol | value | HR (95% CI) | Gene symbol | value | HR (95% CI) | Gene symbol | value | HR (95% CI) |
| | CKAP4 | 0.019 | 1.792 (1.102–2.912) | ITGB5 | 0.042 | 3.017 (1.039–8.763) | PLK2 | 0.010 | 1.221 (1.048–1.422) | | EPS8 | 0.003 | 1.785 (1.213–2.627) | PLK2 | 0.005 | 1.806 (1.198–2.723) | PLS3 | 0.032 | 1.243 (1.019–1.516) | | SCML1 | <0.001 | 1.587 (1.235–2.040) | CTGF | 0.039 | 1.427 (1.018–2.000) | CKAP4 | 0.044 | 1.279 (1.007–1.626) | | RIN2 | 0.014 | 0.651 (0.463–0.916) | ZNF703 | 0.020 | 0.566 (0.351–0.913) | FAM129B | 0.014 | 0.568 (0.361–0.892) | | PPP2R3A | 0.044 | 0.647 (0.424–0.988) | TM4SF1 | 0.042 | 2.162 (1.027–4.551) | SRGAP1 | 0.008 | 1.362 (1.083–1.715) | | TJP1 | 0.007 | 0.520 (0.325–0.834) | ANXA2 | 0.029 | 3.86 (1.147–12.996) | RIN2 | 0.045 | 1.519 (1.010–2.286) | | ANKRD57 | 0.005 | 2.378 (1.296–4.363) | PLEKHA1 | 0.004 | 5.452 (1.695–17.534) | CTBP2 | 0.026 | 1.481 (1.048–2.094) | | ACTN1 | 0.047 | 1.179 (1.002–1.387) | DIP2C | 0.048 | 2.772 (1.009–7.617) | MYO1B | 0.001 | 1.463 (1.174–1.824) | | ANXA2 | 0.008 | 1.324 (1.075–1.631) | LINC01137 | 0.047 | 0.160 (0.026–0.978) | RAI14 | <0.001 | 1.893 (1.466–2.444) | | HTRA1 | <0.001 | 0.549 (0.396–0.763) | SEPT10 | 0.017 | 3.564 (1.249–10.167) | LAMB1 | 0.037 | 1.184 (1.010–1.388) | | TGFBI | 0.048 | 1.140 (1.001–1.298) | GAS2L3 | 0.043 | 0.330 (0.112–0.967) | GNA11 | 0.016 | 0.621 (0.422–0.914) | | DIP2C | 0.001 | 0.541 (0.377–0.778) | LRMP | 0.033 | 1.803 (1.048–3.100) | EMP2 | 0.031 | 0.770 (0.607–0.976) | | TNFRSF12A | 0.005 | 1.358 (1.095–1.685) | GMFG | 0.003 | 3.790 (1.586–9.057) | PFN2 | 0.023 | 1.316 (1.038–1.668)
| | EMP2 | 0.033 | 1.391 (1.028–1.883) | GIMAP6 | 0.024 | 1.877 (1.086–3.243) | CD44 | 0.009 | 0.716 (0.557–0.921) | | CD44 | 0.049 | 1.238 (1.001–1.532) | RCSD1 | 0.015 | 2.684 (1.213–5.939) | RND3 | 0.006 | 1.366 (1.095–1.704) | | SEPT10 | 0.001 | 1.933 (1.294–2.886) | CD69 | 0.044 | 1.361 (1.008–1.837) | NUAK1 | <0.001 | 1.303 (1.125–1.509) | | FAM114A1 | 0.020 | 1.384 (1.052–1.819) | | | | VEGFC | 0.013 | 1.325 (1.062–1.654) | | PRSS23 | 0.006 | 1.294 (1.075–1.557) | | | | GRIK5 | 0.014 | 1.515 (1.089–2.107) | | NUAK1 | 0.018 | 0.689 (0.506–0.939) | | | | | | | | PTK2 | 0.029 | 0.525 (0.294–0.938) | | | | | | | | ANXA2P2 | 0.008 | 1.497 (1.110–2.020) | | | | | | | | GRIK5 | 0.014 | 0.719 (0.552–0.937) | | | | | | | | ACVR2B | 0.006 | 0.622 (0.442–0.874) | | | | | | | | ICAM3 | 0.013 | 1.305 (1.058–1.610) | | | | | | | | BCOR | 0.046 | 1.383 (1.005–1.902) | | | | | | | | IQGAP2 | 0.001 | 1.544 (1.182–2.018) | | | | | | |
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HR: hazard ratio; CI: confidence interval.
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