Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study
Table 2
Haematological findings in rats that were treated orally with multiple LAB strains for 28 days.
Parameters
Control
Multiplex LAB strains
Normal dose
High dose
WBC (103/μL)
M
8.13 ± 0.84a
8.21 ± 1.12a
8.33 ± 0.92a
F
7.29 ± 2.66a
9.5 ± 1.04a
7.93 ± 1.66a
RBC (106/μL)
M
6.84 ± 0.15a
6.64 ± 0.17a
6.8 ± 0.22a
F
6.83 ± 0.41a
6.6 ± 0.31a
6.75 ± 0.2a
Haemoglobin (g/dL)
M
14.69 ± 0.25a
14.69 ± 0.18a
14.94 ± 0.19b
F
14.15 ± 1.06a
14.4 ± 0.2a
14.54 ± 0.29a
Haematocrit (%)
M
44.38 ± 0.1ab
42.66 ± 1.24a
44.28 ± 1.6b
F
42.64 ± 1.06a
41.8 ± 2.24a
42.71 ± 1.95a
MCV (fL)
M
64.33 ± 2.41a
64.25 ± 0.97a
65.18 ± 3.56a
F
62.4 ± 2.16a
63.8 ± 5.77a
63.29 ± 2.72a
MCH (pg)
M
21.44 ± 0.71a
22.13 ± 0.18a
21.99 ± 0.72a
F
20.7 ± 1.05a
21.9 ± 0.8b
21.55 ± 0.54ab
MCHC (%)
M
33.23 ± 0.57a
34.43 ± 0.9a
33.79 ± 1.4a
F
33.21 ± 1.88a
34.5 ± 2.29a
34.08 ± 1.08a
Platelet (103/μL)
M
720 ± 53.84a
769.5 ± 146.9a
832.25 ± 154.2a
F
707.75 ± 281.54a
774.3 ± 187.43a
780.38 ± 91.37a
All values are represented as the mean ± S.D. of Wistar rat ( = 7-8/sex/dose). WBC: mean white blood cell; RBC: mean red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; M: male; F: female.
a,b compared with the control group by ANOVA followed by Dunnett’s test.