Formulation Optimization of Arecoline Patches

Table 1

The composition and responses (penetration rate and adhesion) of model arecoline-loaded patches.

	𝑋1	𝑋2	𝑋3	𝑋4	𝑋5	Response	Response
	(g)	(g)	(g)	(g)	(g)	Flux (𝜇g/cm^2/h)	Adhesion (cN/cm)
F1	0.60	0.20	0.20	0.20	0.20	80.83±15.78	18.07±3.94
F2	0.40	0.20	0.40	0.20	0.05	19.05±3.62	49.58±8.02
F3	0.20	0.20	0.60	0.25	0.20	22.24±2.76	254.63±37.92
F4	0.20	0.40	0.40	0.20	0.05	25.18±8.29	52.83±7.40
F5	0.60	0.20	0.20	0.20	0.05	26.99±12.29	6.20±1.08
F6	0.20	0.60	0.20	0.25	0.05	9.67±4.30	6.52±3.15
F7	0.33	0.33	0.33	0.23	0.13	47.14±11.62	62.05±7.02
F8	0.20	0.40	0.40	0.25	0.05	0.59±0.09	86.55±16.50
F9	0.20	0.20	0.60	0.20	0.05	7.22±0.97	85.48±12.15
F10	0.40	0.40	0.20	0.20	0.05	14.17±0.42	40.37±7.81
F11	0.20	0.60	0.20	0.33	0.20	34.60±16.41	57.42±15.38
F12	0.40	0.20	0.40	0.20	0.20	40.20±26.53	216.38±25.08
F13	0.40	0.40	0.20	0.25	0.05	6.53±1.33	33.72±5.85
F14	0.60	0.20	0.20	0.25	0.20	111.11±42.84	33.12±6.49
F15	0.20	0.40	0.40	0.20	0.05	15.86±6.02	56.88±4.15
F16	0.60	0.20	0.20	0.33	0.20	20.31±8.12	41.12±5.23
F17	0.20	0.20	0.60	0.25	0.05	11.40±1.12	231.80±34.61
F18	0.60	0.20	0.20	0.24	0.09	37.20±4.73	22.79±3.94
F19	0.40	0.20	0.40	0.25	0.05	0.96±0.05	29.44±4.31
F20	0.20	0.40	0.40	0.20	0.20	36.85±5.44	163.69±24.97
F21	0.20	0.60	0.20	0.20	0.05	7.06±0.62	5.00±0.88
F22	0.20	0.20	0.60	0.33	0.20	52.14±11.23	48.39±7.23
F23	0.20	0.60	0.20	0.20	0.20	54.48±19.79	59.97±13.78
F24	0.20	0.20	0.60	0.21	0.16	38.66±0.23	76.93±12.29
F25	0.40	0.40	0.20	0.25	0.20	43.12±15.53	22.98±2.51

(1) The amount of each formulation was given an area of 64 cm² of arecoline-loaded patch.
(2) The 𝑋₁, 𝑋₂, 𝑋₃, 𝑋₄, and 𝑋₅ were the weight of Eudragit RL 100, Eudragit RS 100, PVP K30, PEG 400, and arecoline.