Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

Figure 1

Effect of antioxidants on ALA-S activity. Mice received standard diet containing Gris (0.5%, w/w) and antioxidants in drinking water: Tx (2 mg/100 mL), Asc (12 mg/100 mL), Tx (2 mg/100 mL) plus Asc (12 mg/100 mL), EA (300 mg/L), Que (50 mg/L), CA (50 mg/L), CfA (650 mg/L), GA (50 mg/L), FA (60 mg/L), or Mel (5 mg/kg ip, 72, 48, 24, or 1 hour before sacrifice); over 14 days. Control group received only standard diet in oil (vehicle used for solubilised Gris). Results are expressed as percentage ± SD of 6 mice of the corresponding control value taken as 100% (dotted line). Mean control value: 0.144±0.021 nmol/mg protein. ^∗∗𝑃<0.01: significant difference between the group treated with Gris alone or Gris plus antioxidant and the control group. ⁺⁺𝑃<0.01: significant difference between the group treated with Gris plus antioxidant and the group that only received Gris. ^††𝑃<0.01: Significant difference between the group treated with Gris plus antioxidant and the group only treated with antioxidant. Experimental details are described in Section 2.