Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

Table 1

Effect of antioxidants on liver PROTO IX levels.

Gris	PROTO IX levels (ng/mg protein)
	Control	Tx	Asc	TX + Asc	Mel	EA	Que	CA	CfA	GA	FA
Without	0.42±0.04	0.45±0.06	0.41±0.05	0.43±0.04	0.44±0.03	0.45±0.01	0.41±0.03	0.44±0.03	0.47±0.05	0.36±0.04	0.48±0.03
With	20.32±3.15^∗∗	19.85 ±2.28∗∗††	21.01±3.51^∗∗††	20.40±3.24^∗∗††	17.88±3.78^∗∗††	22.63±4.21^∗∗††	18.62±3.84^∗∗††	19.76±4.02^∗∗††	24.16±5.20^∗∗††	19.57±3.65^∗∗††	21.96±3.98^∗∗††

Mice received standard diet containing Gris (0.5%, w/w); in the drinking water, they also received Tx (2 mg/100 mL), Asc (12 mg/100 mL), Tx (2 mg/100 mL) plus Asc (12 mg/100 mL), ellagic acid (EA, 300 mg/L), Que (50 mg/L), CA (50 mg/L), CfA (650 mg/L), GA (50 mg/L), FA (60 mg/L), or Mel (5 mg/kg ip, 72, 48, 24 or 1 hour before sacrifice), over 14 days. Control group received only standard diet of oil (vehicle used for solubilised Gris). Data represent mean values ± SD of 6 mice. ^∗∗𝑃<0.01: significant difference between the group treated with Gris alone or Gris plus antioxidant and the control group. ^††𝑃<0.01: significant difference between the group treated with Gris plus antioxidant and the group only treated with antioxidant. Other experimental details are described in Section 2.