Research Article
Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer
Table 2
Morphometric parameters of colon mucosa, adjacent to colonic tumors for rats treated by D1 and 5FU under DMH-induced carcinogenesis. Mean ± SEM,
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| | | Mucosa thickness, m | Colonocytes height, m | Colonocytes nuclei cross-sectional area, m2 | Goblet cells cross-sectional area, m2 | Mitotic index, % |
| | Control | 210.64 ± 9.62 | 16.75 ± 0.87 | 14.93 ± 1.22 | 107.08 ± 11.3 | 4.25 ± 0.32 |
| | 233.12 ± 10.39 () | 18.69 ± 0.70 () | 17.83 ± 1.31 () | 99.01 ± 8.73 | 3.58 ± 0.32 |
| | 186.00 ± 7.9 () | 17.04 ± 0.63 | 15.16 ± 0.84 | 99.76 ± 7.95 | 3.10 ± 0.43 () |
| | 5FU | 208.61 ± 9.18 | 18.53 ± 0.92 () | 14.09 ± 0.61 | 99.67 ± 7.59 | 2.66 ± 0.75 () |
| | DMH | 238.56 ± 11.64 () | 20.93 ± 1.18 () | 18.59 ± 1.03 () | 108.01 ± 9.27 | 4.20 ± 0.26 |
| | DMH + | 209.48 ± 9.35 (, ) | 19.05 ± 0.84 () | 15.80 ± 0.81 (, ) | 99.96 ± 6.72 | 3.70 ± 0.35 () |
| | DMH + | 257.97 ± 11.64 (, , ) | 18.60 ± 0.88 (, ) | 14.60 ± 1.08 (, ) | 130.63 ± 14.3 (, , ) | 3.03 ± 0.24 (, ) |
| | DMH + 5FU | 282.65 ± 12.95 (, ) | 18.47 ± 0.7 (, ) | 18.08 ± 1.11 () | 100.91 ± 6.78 | 2.87 ± 0.23 (, ) |
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values indicated in comparison with control; compared to DMH group; compared to DMH + 5FU group: for DMH + and DMH + groups.
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