Research Article
Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer
Table 5
Liver parameters for rats treated by D1 and 5FU under DMH-induced carcinogenesis. Mean ± SEM,
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| | | Centrolobular lobulae | Periportal lobulae |
Sinusoids diameter, m | | | Hepatocyte cross-sectional area, m2 | Hepatocyte nuclei cross-sectional area, m2 | Hepatocyte cross-sectional area, m2 | Hepatocyte nuclei cross-sectional area, m2 |
| | Control | 310.07 ± 3.03 | 46.23 ± 0.31 | 282.74 ± 2.58 | 45.21 ± 0.28 | 4.37 ± 0.08 |
| | 348.45 ± 2.14 () | 48.57 ± 0.33 | 318.47 ± 2.78 () | 46.16 ± 0.32 | 4.81 ± 0.07 () |
| | 339.63 ± 2.47 () | 47.93 ± 0.34 | 309.55 ± 2.66 () | 46.1 ± 0.33 | 4.51 ± 0.09 |
| | 5FU | 333.98 ± 2.51 () | 45.32 ± 0.32 | 317.98 ± 2.84 () | 44.25 ± 0.27 | 4.52 ± 0.07 |
| | DMH | 366.61 ± 1.50 () | 55.59 ± 0.16 () | 350.5 ± 1.97 () | 51.02 ± 0.34 () | 5.12 ± 0.04 () |
| | DMH + | 364.32 ± 1.81 () | 55.49 ± 0.15 () | 358.07 ± 1.77 () | 52.04 ± 0.29 () | 5.31 ± 0.04 () |
| | DMH + | 370.58 ± 1.30 (, ) | 54.06 ± 0.22 (, ) | 351.86 ± 2.11 () | 50.89 ± 0.30 () | 4.95 ± 0.06 |
| | DMH + 5FU | 355.97 ± 2.00 (, ) | 55.82 ± 0.14 () | 349.06 ± 2.19 () | 52.19 ± 0.28 () | 5.04 ± 0.04 () |
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values indicated in comparison with control; compared to DMH group; compared to DMH + 5FU group: for DMH + and DMH + groups.
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