The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes

Figure 2

Cyclophosphamide- (CYP-) induced cystitis increases substance P (Sub P) in the urinary bladder and cystometric fluid and the antioxidant, Tempol, reduces expression. (a) 4 hr and 48 hr CYP-induced cystitis significantly () increased Sub P expression in urinary bladder that was significantly reduced with Tempol. Tempol was without effect on Sub P expression in urinary bladder from control (no CYP) rats. (b) 4 hr and 48 hr CYP-induced cystitis significantly () increased Sub P expression in cystometric fluid that was significantly () reduced with Tempol. Tempol was without effect on Sub P expression in cystometric fluid from control (no CYP) rats. . for control and treatment groups.

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(b)