Bone Morphology in 46 BXD Recombinant Inbred Strains and Femur-Tibia Correlation
Table 1
value of strain effect on bone morphological and biomechanical properties in femur and tibia of RI mice adjusted for gender and age ().
Measurement*
Bone
Number of strains
Percentage of females
Age range (week)
Strain
Gender
Age
Length
Femur
46
48.9
9.6–13.6
<0.0001
<0.0001 (F−)
0.04 (+)
Tibia
46
52.0
9.6–13.6
<0.0001
0.075 (F−)
0.23
mBMD
Femur
46
48.9
9.6–13.6
<0.0001
0.051 (F+)
0.8
Tibia
46
52.0
9.6–13.6
<0.0001
0.53
0.096 (+)
Min. Vol
Femur
46
49.5
9.6–13.6
<0.0001
<0.0001 (F−)
0.039 (+)
Tibia
46
52.0
9.6–13.6
<0.0001
<0.0001 (F−)
0.35
Ct. Th
Femur
46
55.8
9.6–13.6
<0.0001
<0.0001 (F−)
0.22
Tibia
46
54.5
9.6–13.6
<0.0001
<0.0001 (F−)
0.18
Ct. mBMD
Femur
46
55.8
9.6–13.6
<0.0001
0.014 (F−)
0.86
Tibia
46
54.5
9.6–13.6
<0.0001
0.02 (F−)
0.09 (+)
CSA
Femur
46
55.8
9.6–13.6
0.0048
<0.0001 (F−)
0.59
Tibia
46
54.5
9.6–13.6
0.01
0.0001 (F−)
0.21
Ct. Ar
Femur
46
55.8
9.6–13.6
<0.0001
<0.0001 (F−)
0.82
Tibia
46
54.5
9.6–13.6
<0.0001
<0.0001 (F−)
0.43
Trab. BV/TV
Femur
46
53.9
9.6–13.6
<0.0001
<0.0001 (F−)
0.4
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F−)
0.8
Conn. Dens
Femur
46
53.9
9.6–13.6
<0.0001
<0.0001 (F−)
0.05 (−)
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F−)
0.087 (−)
Trab. SMI
Femur
46
53.8
9.6–13.6
<0.0001
<0.0001 (F+)
0.48
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F+)
0.81
Trab. N
Femur
46
53.9
9.6–13.6
<0.0001
<0.0001 (F−)
0.017 (−)
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F−)
0.25
Trab. Th
Femur
46
53.9
9.6–13.6
<0.0001
<0.0001 (F−)
0.87
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F−)
0.01 (+)
Trab. Sp
Femur
46
53.9
9.6–13.6
<0.0001
<0.0001 (F+)
0.009 (+)
Tibia
46
53.7
9.7–13.6
<0.0001
<0.0001 (F+)
0.35
Trab. mBMD
Femur
46
53.9
9.6–13.6
<0.0001
0.0007 (F−)
0.23
Tibia
46
53.7
9.7–13.6
<0.0001
0.018 (F−)
0.65
Trab. DA
Femur
46
53.9
9.6–13.6
<0.0001
0.15
0.1 (−)
Tibia
46
53.7
9.7–13.6
<0.0001
0.08 (F−)
0.91
values no greater than 0.05 are in italic and they are in bold if they were larger than 0.05 but less than 0.1. F+ means females have higher values; F− means females have lower values. (−) refers to negative association; (+) refers to positive association. Min. Vol = mineral volume, Ct. Th = cortical thickness (mm), CSA = cross-sectional area (mm2), Ct. Ar = cross-sectional area of cortical bone (mm2), Trab. BV/TV = trabecular bone volume density or bone volume ratio, Conn. Dens = connectivity density, Trab. SMI = trabecular structural model index, Trab. N = trabecular number, Trab. Th = trabecular thickness, Trab. Sp = trabecular space, Trab. mBMD = trabecular material bone mineral density, and Trab. DA = trabecular degree of anisotropy.
