System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach

Table 1

The functional characterization of protein interaction networks in three clusters.

Cluster		GO:term	Term name	value
Cluster 1	Biological processes	GO:0016568	Chromatin modification
		GO:0006325	Chromatin organization
		GO:0051568	Histone H3-K4 methylation
	Cellular components	GO:0034708	Methyltransferase complex
		GO:0035097	Histone methyltransferase complex
		GO:0044451	Nucleoplasm part
	Molecular functions	GO:0042054	Histone methyltransferase activity
		GO:0008170	N-Methyltransferase activity
		GO:0008276	Protein methyltransferase activity
Cluster 2	Biological processes	GO:0045944	Positive regulation of transcription from RNA polymerase II promoter
		GO:0006357	Regulation of transcription from RNA polymerase II promoter
		GO:0010628	Positive regulation of gene expression
	Cellular components	GO:0005634	Nucleus
		GO:0044451	Nucleoplasm part
		GO:0005667	Transcription factor complex
	Molecular functions	GO:0008134	Transcription factor binding
		GO:0016563	Transcription activator activity
		GO:0030528	Transcription regulator activity
Cluster 3	Biological processes	GO:0000082	G1/S transition of mitotic cell cycle
		GO:0007049	Cell cycle
		GO:0022402	Cell cycle process
	Cellular components	GO:0000307	Cyclin-dependent protein kinase holoenzyme complex
		GO:0005654	Nucleoplasm
		GO:0044428	Nuclear part
	Molecular functions	GO:0004693	Cyclin-dependent protein kinase activity
		GO:0016538	Cyclin-dependent protein kinase regulator activity
		GO:0030332	Cyclin binding