Research Article
System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach
Table 1
The functional characterization of protein interaction networks in three clusters.
| Cluster | GO:term | Term name | value |
| Cluster 1 | Biological processes | GO:0016568 | Chromatin modification | | GO:0006325 | Chromatin organization | | GO:0051568 | Histone H3-K4 methylation | | Cellular components | GO:0034708 | Methyltransferase complex | | GO:0035097 | Histone methyltransferase complex | | GO:0044451 | Nucleoplasm part | | Molecular functions | GO:0042054 | Histone methyltransferase activity | | GO:0008170 | N-Methyltransferase activity | | GO:0008276 | Protein methyltransferase activity | |
| Cluster 2 | Biological processes | GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | | GO:0006357 | Regulation of transcription from RNA polymerase II promoter | | GO:0010628 | Positive regulation of gene expression | | Cellular components | GO:0005634 | Nucleus | | GO:0044451 | Nucleoplasm part | | GO:0005667 | Transcription factor complex | | Molecular functions | GO:0008134 | Transcription factor binding | | GO:0016563 | Transcription activator activity | | GO:0030528 | Transcription regulator activity | |
| Cluster 3 | Biological processes | GO:0000082 | G1/S transition of mitotic cell cycle | | GO:0007049 | Cell cycle | | GO:0022402 | Cell cycle process | | Cellular components | GO:0000307 | Cyclin-dependent protein kinase holoenzyme complex | | GO:0005654 | Nucleoplasm | | GO:0044428 | Nuclear part | | Molecular functions | GO:0004693 | Cyclin-dependent protein kinase activity | | GO:0016538 | Cyclin-dependent protein kinase regulator activity | | GO:0030332 | Cyclin binding | |
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