Proper function of the cardiovascular system is indispensable to human survival. However, many complex interactions, physiological and pathological processes, and underlying mechanisms in the cardiovascular system remain unknown. Numerical and analytical modeling becomes a powerful tool in delineating these mechanisms and providing biomechanical insight. Computer-based simulations of dynamic processes in the cardiovascular system could be applied to numerous problems.

The simulation of blood flow is of great importance for understanding the function of the cardiovascular system under normal and abnormal conditions, designing cardiovascular devices, and diagnosing and treating associated disease. It is helpful and economical for the physician to utilize computational tools to construct and evaluate a combined anatomic/physiologic model to predict the outcome of alternative treatment plans for an individual patient.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to computational simulation and its application in cardiovascular system. We are particularly interested in articles describing the new modalities for clinical characterization of cardiovascular diseases, and the underlying mechanisms of the initiation, development, and treatment of these diseases using numerical simulation methods. Potential topics include, but are not limited to:

• Modeling and computational cardiovascular biology
• Cardiovascular diseases and computer-aided surgical planning
• Hemodynamics and pulse wave propagation in cardiovascular system
• Fluid-Structure Interaction of cardiovascular system
• Computational cardiac electrophysiology
• Multiscale modeling of cardiovascular system
• Interventional treatment of vascular diseases
• Modeling of the heart electrophysiology and myocardium mechanics at various levels of organization (from subcellular one to the whole heart)
• Computational biomechanics of heart and blood vessels
• Computational fluid dynamics method and application in cardiovascular system
• Mathematical models for the integrated cardiovascular system
• High performance computation of cardiovascular system

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/tswj/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/tswj/computational.biology/cscvs/ according to the following timetable: