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Ulcers
Volume 2011 (2011), Article ID 282507, 7 pages
http://dx.doi.org/10.1155/2011/282507
Review Article

Cytomegalovirus Reactivation in Ulcerative Colitis Patients

1Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
2Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijianzuang, Hebei 05000, China
3Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Davis Building, Room 4066, Los Angeles, CA 90048, USA

Received 14 August 2010; Accepted 15 November 2010

Academic Editor: T. Arakawa

Copyright © 2011 Minh Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ulcerative colitis (UC) patients are believed to have an increased risk for the colonic reactivation of cytomegalovirus (CMV) infection due to both inherent and iatrogenic factors. Numerous studies and case reports have described CMV infection as complicating the disease course of ulcerative colitis patients; the existing evidence suggests an association between the presence of CMV infection and increased colectomy and mortality rates in UC patients. Whether CMV is nonpathogenic with a tropism towards areas of dysplasia and inflammation in the colon of UC or plays an active role in pathogenesis is still debated. In this paper, we examine the existing evidence for the diagnosis and management of CMV infection in UC patients.