Table 1: Summary of diagnostic techniques and its characteristics for CMV infection.

Diagnostic testsProsConsSensitivitySpecificity

Serum serologyCan detect evidence of prior infectionUnable to detect active colitis98%–100% [27, 28]96%–99%
[27, 28]
Antigen testingReasonable sensitivity and specificity for active diseaseSemiquantitative, results subjective60%–100% [2931]83%–100% [2931]
CultureHigh specificityPoor sensitivity; long incubation;45%–78% [30, 32]89%–100% [27, 30]
DNA PCR (Serum)High negative predictive value, may correlate with active diseaseDifferent assays and quantitation methods; low specificity65%–100%
[29, 30, 33]
40%–92%
[30, 33, 34]
Histologic H&E stainInexpensive stainPoor sensitivity10%–87%
[35]
92%–100%
[35]
Histologic IHC stainingImproves sensitivity over H&E stainingExpensive stain78%–93% [35]92%–100% [35]