Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis
Figure 1
EGFR activation induced by nitric oxide and peroxynitrite. Quoted from [32] and modified. Peroxynitrite, ONOO- promotes EGFR dimerization and phosphorylation, which is followed by activation of extracellular-regulated kinases (ERK) 1 and 2, via activation of Ras and mitogen-activated protein kinase kinase (MKK) 1 or 2. Nitric oxide, NO promotes EGFR autophosphorylation through activation of ERK. P indicates phosphorylation.
