Research Article
Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary?
Table 2
Putative genetic factors predisposing to VLU development.
| | Detected genetic abnormality | Population | Author | Journal | Year |
| (1) | F5 gene R506Q (Leiden)* | German | Peus et al. | J Am Acad Dermatol | 1996 | (2) | F2 gene G20210A* | Romanian | Jebeleanu et al. | J Cell Mol Med | 2001 | (3) | F13A gene V34L | Italian | Gemmati et al. | Wound Repair Regen | 2004 | (4) | FGFR2 gene 3′ UTR A2451G* | Hungarian | Nagy et al. | J Invest Dermatol | 2005 | (5) | ESRB gene CA repeat D14S1026 | UK | Ashworth et al. | J Steroid Biochem Mol Biol | 2005 | (6) | HFE gene C282Y | Italian | Zamboni et al. | J Vasc Surg | 2005 | (7) | TNFA gene promoter −308* | Australian | Wallace et al. | J Invest Dermatol | 2006 | Hungarian | Nagy et al. | J Invest Dermatol | 2007 | (8) | FPN1 gene promoter −8GG | Italian | Gemmati et al. | J Vasc Surg | 2009 | (9) | MMP12 gene promoter −82AA | Italian | Gemmati et al. | J Vasc Surg | 2009 | (10) | Sex chromosome aberrations | Austrian | Gattringer et al. | Acta Derm Venereol | 2010 | (47,XXY/48,XXXY karyotype) |
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*The distributions of the genotypes and the allele frequencies of these genetic factors were compared in the present study.
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