Accumulation of Mast Cells in the Lesions and Effects of Antiallergic Drugs on the Patients with Inflammatory Bowel Disease

Table 1

Basic pharmacological activity of IPD.

(A) Immunomodulating activity
(1) Suppression of IgE antibody production (murine, cultured human cell)
(2) Suppression of Th2 cytokine production (murine, human cell)
(3) Suppression of thymus and activation-regulated chemokine (TARC) production
(4) Modulation of toll-like receptors 2 and 4 on antigen-presenting cells in rats
(5) Augmentation of aging-induced downregulated IgE production in mice
(B) Anti-inflammatory activity
(1) Inhibition of histamine release from rat mast cells
(2) Inhibition of murine eosinophil chemotaxis
(3) Inhibition of EG2 positive eosinophil and CD4 or CD25 positive T-cell accumulation in human airway
(4) Inhibition of human eosinophil degranulation
(5) Inhibition of IL-4 induced vascular cell adhesion molecule 1 (VCAMI) expression on human umbilical vein endothelial cells
(C) Experimental asthma
(1) Inhibition of air-flow limitation (mice, guinea pigs)
(2) Inhibition of airway hyperresponsiveness (mice, guinea pigs)
(3) Inhibition of goblet-cell metaplasia of mice airway epithelium