Veterinary Medicine International

Research Article

Histological and Immunohistochemical Evaluation of Autologous Cultured Bone Marrow Mesenchymal Stem Cells and Bone Marrow Mononucleated Cells in Collagenase-Induced Tendinitis of Equine Superficial Digital Flexor Tendon

Table 1

Morphological and immunohistochemical scores evaluated for each horse at 21 weeks following treatment of collagenase-induced tendinitis SDFT, superficial digital flexor tendon; RH, right hind limb; LF, left fore limb; RF, right fore limb; cBMSCs, cultured bone marrow mesenchymal cells; BMMNCS, bone marrow mononucleated cells; FOS, fiber orientation score; MCI, mononucleated cell infiltration score; Collagen I, type I collagen fiber expression score; Collagen III, type III collagen fiber expression score; COMP, cartilage oligomeric matrix protein expression score; CD34, score describing presence of CD34+ mononuclear cells localized throughout the damaged area of the SDFT (see Section 2 for more details). Significant differences from placebo group: #P<.05.
TreatmentHistological and immunohistochemical scores
FOSMCICollagen ICollagen IIICOMPCD34
cBMSCs3.01.62.61.22.21.0
sd0.00.50.50.40.40.7
BMMNCS3.02.43.01.42.42.0
sd0.00.50.00.50.50.7
Fibrin0.50.51.03.00.50.0
sd0.70.70.00.00.70.0
Placebo0.80.51.32.31.30.0
sd1.00.60.50.50.50.0