Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Table 1

Summary of first-line antimicrobial options for UTIs in the dog and cat.

Infection Type	First-line drug options
Uncomplicated UTI	Amoxicillin, trimethoprim-sulfonamide
Complicated	Guided by culture and susceptibility testing, but consider amoxicillin or trimethoprim-sulfonamide initially
Subclinical bacteriuria	Antimicrobial therapy not recommended unless high risk for ascending infection. If so, treat as per complicated UTI
Pyelonephritis	Start with a fluoroquinolone, with re-assessment based on culture and susceptibility testing