Hemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C

Table 2

Effect of chronic exposure to soya oil (S/oil), vitamin C (VC), and/or chlorpyrifos (CPF) on absolute total and differential leukocyte count in Wistar rats.

Parameters (×10^9/L)	S/oil	VC	CPF	VC+CPF
Total leukocyte count (×10^9/L)	9.9 ± 0.81a	9.9 ± 0.89	5.4 ± 0.37ab	8.4 ± 0.5i
Neutrophils count (×10^9/L)	4.4 ± 0.12	4.9 ± 0.19	2.7 ± 0.15abc	3.4 ± 0.16de
Lymphocytes count (×10^9/L)	5.3 ± 0.18	5.9 ± 0.16	3.0 ± 0.13abf	4.5 ± 0.19eg
Monocytes count (×10^9/L)	0.07 ± 0.01	0.09 ± 0.02	0.0 ± 0,0ch	0.03 ± 0.01i
Band cells count (×10^9/L)	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.01 ± 0.003
Neutrophil : Lymphocyte ratio	0.84 ± 0.05	0.82 ± 0.09	1.0 ± 0.0abc	0.76 ± 0.04

^a𝑃<.01 versus soya oil group; ^b𝑃<.01 versus vitamin C group; ^c𝑃<.05 versus vitamin C+chlorpyrifos group; ^d𝑃<.01 versus Soya oil group; ^e𝑃<.01 versus Vitamin C group; ^f𝑃<.01 versus vitamin C+chlorpyrifos group; ^g𝑃<.05 versus Soya oil group; ^h𝑃<.05 versus soya oil group; ⁱ𝑃<.05 versus vitamin C group. Values are mean ± SEM of 5 animals per group.