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Veterinary Medicine International
Volume 2012 (2012), Article ID 207950, 4 pages
http://dx.doi.org/10.1155/2012/207950
Research Article

Copper Deficiency in Sheep with High Liver Iron Accumulation

1Departamento de Clinica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Avenida Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil
2Departamento de Ciências Animais, Universidade Federal Rural do Semiárido, 59.625-900 Mossoró, RN, Brazil

Received 7 September 2012; Revised 14 November 2012; Accepted 15 November 2012

Academic Editor: Marta I. Miranda Castañón

Copyright © 2012 Isadora Karolina Freitas de Sousa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An outbreak of enzootic ataxia among sheep raised in the northeastern region of Brazil is described. Copper (Cu) deficiency was diagnosed in a herd of 56 sheep, among which five presented characteristic clinical symptoms of enzootic ataxia. The symptoms began 30 days after birth, with a clinical condition that included locomotion difficulty, limb ataxia, tremors, and continual falls. Liver biopsies were performed and blood was collected to determine hepatic and plasmatic Cu, iron (Fe), and zinc (Zn) concentration, respectively. The laboratory results showed that the animals presented low copper concentrations in the plasma and liver, without difference between the clinically healthy animals and those affected by enzootic ataxia. Even after supplementation with adequate Cu levels had been recommended, it was found on a new visit to the farm four months later that one animal still presented a clinical condition and that the hepatic Cu levels of the herd had not risen. Despite the low copper content of the diet, the high hepatic Fe levels found suggest that antagonism due to this element may have been an important factor in triggering copper deficiency in these animals, and thus, additional copper supplementation may be necessary for these animals.