Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review

Figure 1

Schematic overview of the classical cadherin-catenin complex. Classical cadherins (blue), which mediate calcium-dependent (red) intercellular adhesion, are composed by an extracellular domain, a transmembrane domain and a cytoplasmic domain. This one comprises a juxtamembrane domain, which binds to p120-catenin (orange), and a catenin-binding domain, which binds β-catenin (yellow). β-catenin binds to α-catenin (violet), which establishes a direct link between the cadherin-catenin complex and the actin cytoskeleton (red).