Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs

Table 1

Summary of GI transit times in healthy dogs measured using the WMC system before and during treatment with ranitidine. % CV = coefficient of variation. Between-subject and within-subject coefficients of variation were calculated based on measurements taken prior to treatment with ranitidine. P values are for testing the null hypothesis that transit time does not differ among the 4 repetitions (3 before treatment with ranitidine and the 4th during treatment with ranitidine). ^*: nonparametric data, transit times for the 4 repetitions were compared using a Friedman’s test; ^**: parametric data, transit times for the 4 repetitions were compared using a repeated measures ANOVA.

Transit time	Between-subject % CV	Within-subject % CV	Median before ranitidine	Median with ranitidine	P value
			(range; minutes)	(range; minutes)
Gastric emptying time	26.9%	9.3%	719 (622–1,320)	757 (628–1,128)	0.6149^*
Small intestinal	29.2%	24.8%	183 (92–290)	162 (86–215)	0.5007^**
Large intestinal	35.4%	20.5%	1,398 (644–2,445)	1,140 (342–2,481)	0.6172^**
Small and large intestinal	32.3%	19.6%	1,636 (746–2,588)	1,227 (490–2,634)	0.6215^**
Total gastrointestinal	19.6%	15.9%	2,735 (1,898–3,296)	2,083 (1,248–3,262)	0.2759^*