About this Journal Submit a Manuscript Table of Contents
Veterinary Medicine International
Volume 2013 (2013), Article ID 786162, 7 pages
http://dx.doi.org/10.1155/2013/786162
Research Article

E. coli-Derived L-Asparaginase Retains Enzymatic and Cytotoxic Activity In Vitro for Canine and Feline Lymphoma after Cold Storage

Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Hazelwood Drive, Urbana, IL 61802, USA

Received 12 December 2012; Accepted 15 March 2013

Academic Editor: Sagar M. Goyal

Copyright © 2013 Jackie M. Wypij and Holly C. Pondenis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Louwerens, C. A. London, N. C. Pedersen, and L. A. Lyons, “Feline lymphoma in the post-feline leukemia virus era,” Journal of Veterinary Internal Medicine, vol. 19, no. 3, pp. 329–335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Kaiser, “Animal neoplasia: a systemic review,” in Neoplasms: Comparative Pathology in Animals, Plants and Man, H. Kaiser, Ed., Williams & Wilkins, Baltimore, Md, USA, 1st edition, 1981.
  3. J. E. Moulton and J. W. Harvey, “Tumors of lymphoid and hematopoietic tissue,” in Tumor of Domestic Animals, J. E. Moulton, Ed., University of California, 3rd edition, 1990.
  4. W. D. Hardy, “Hematopoietic tumors of cats,” Journal of the American Animal Hospital Association, vol. 17, no. 6, pp. 921–940, 1981. View at Scopus
  5. C. Couto, “Oncology,” in The Cat: Diseases and Clinical Management, R. Sherding, Ed., Churchill Livingstone, New York, NY, USA, 1st edition, 1989.
  6. E. G. MacEwen, R. C. Rosenthal, L. E. Fox, A. S. Loar, and I. D. Kurzman, “Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma,” Journal of Veterinary Internal Medicine, vol. 6, no. 4, pp. 230–234, 1992. View at Scopus
  7. K. L. Boyce and B. E. Kitchell, “Treatment of canine lymphoma with COPLA/LVP,” Journal of the American Animal Hospital Association, vol. 36, no. 5, pp. 395–403, 2000. View at Scopus
  8. C. H. Zwahlen, M. D. Lucroy, S. A. Kraegel, and B. R. Madewell, “Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993–1997),” Journal of the American Veterinary Medical Association, vol. 213, no. 8, pp. 1144–1149, 1998. View at Scopus
  9. D. Simon, N. Eberle, L. Laacke-Singer, and I. Nolte, “Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats,” Journal of Veterinary Internal Medicine, vol. 22, no. 2, pp. 394–400, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. A. K. LeBlanc, S. K. Cox, C. A. Kirk, S. J. Newman, J. W. Bartges, and A. M. Legendre, “Effects of L-asparaginase on plasma amino acid profiles and tumor burden in cats with lymphoma,” Journal of Veterinary Internal Medicine, vol. 21, no. 4, pp. 760–763, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. Lundbeck Pharmaceuticals, Ed., Elspar, Deerfield, Ill, USA, 2012.
  12. F. Jameel, D. Kalonia, and R. Bogner, “The effect of hetastarch on the stability of L-asparaginase during freeze- thaw cycling,” PDA Journal of Pharmaceutical Science and Technology, vol. 49, no. 3, pp. 127–131, 1995. View at Scopus
  13. D. I. Marlborough, D. S. Miller, and K. A. Cammack, “Comparative study on conformational stability and subunit interactions of two bacterial asparaginases,” Biochimica et Biophysica Acta, vol. 386, no. 2, pp. 576–589, 1975. View at Scopus
  14. D. Cappelletti, L. R. Chiarelli, M. V. Pasquetto, S. Stivala, G. Valentini, and C. Scotti, “Helicobacter pylori l-asparaginase: a promising chemotherapeutic agent,” Biochemical and Biophysical Research Communications, vol. 377, no. 4, pp. 1222–1226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. D. Story, D. W. Voehringer, L. C. Stephens, and R. E. Meyn, “L-Asparaginase kills lymphoma cells by apoptosis,” Cancer Chemotherapy and Pharmacology, vol. 32, no. 2, pp. 129–133, 1993. View at Scopus
  16. B. L. Asselin, D. Ryan, C. N. Frantz et al., “In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase,” Cancer Research, vol. 49, no. 15, pp. 4363–4368, 1989. View at Scopus
  17. A. Neubauer, H. Sauer, and G. Valet, “Cytostatic drug testing in human leukemias by means of multiparametric flow cytometry,” Blut, vol. 55, no. 5, pp. 433–445, 1987. View at Scopus
  18. T. Ueno, K. Ohtawa, K. Mitsui et al., “Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase,” Leukemia, vol. 11, no. 11, pp. 1858–1861, 1997. View at Scopus
  19. A. G. Bosanquet, “Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumour agents,” Cancer Chemotherapy and Pharmacology, vol. 23, no. 4, pp. 197–207, 1989. View at Scopus
  20. A. L. Stecher, P. Morgantetti De Deus, I. Polikarpov, and J. Abrahão-Neto, “Stability of L-asparaginase: an enzyme used in leukemia treatment,” Pharmaceutica Acta Helvetiae, vol. 74, no. 1, pp. 1–9, 1999. View at Publisher · View at Google Scholar · View at Scopus