Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken

Table 3

Effect of repeated oral administration of 25 mg/kg BW of tilmicosin daily for 5 consecutive days on some biochemical parameters in broiler chicken (𝑛=5).

Parameters	Days
	Control	1	5	10	15	20
Creatinine (mg/dL)	1.67±0.20	1.79±0.03	1.81±0.07	1.90±0.07	1.88±0.05	1.92±0.06
Uric acid (mg/dL)	5.31±0.17	5.89±0.23	5.94±0.39	5.90±0.12	5.78±0.06	5.78±0.08
Sodium (mmol/L)	115.6±10.85^ab	94.6±0.92^c	100.6±2.56^bc	105.8±1.07^abc	110±3.36^abc	118.4±4.01^a
Potassium (mmol/L)	5.15±0.14^c	5.45±0.13^abc	5.32±0.20^bc	5.68±0.06^ab	5.77±0.06^ab	5.81±0.13^a
Calcium (mg/dL)	9.44±0.14^ab	9.59±0.13^a	9.75±0.11^a	9.97±0.24^a	9.88±0.09^a	9.01±0.20^b
Glucose (mg/dL)	111.41±2.61^ab	118.91±3.96^a	120.63±5.57^a	122.39±3.43^a	107.63±2.86^b	117.70±1.24^ab
T. protein (g/dL)	4.80±0.32^a	3.57±0.15^b	3.46±0.12^b	3.87±0.11^b	4.51±0.16^a	4.68±0.07^a
Albumin (g/dL)	2.26±0.09^a	1.50±0.07^b	1.18±0.03^c	1.25±0.06^c	2.24±0.06^a	2.22±0.07^a
AST (U/L)	176.53±3.91^b	185.54±4.62^ab	186.1±3.10^ab	176.49±1.66^b	188.56±7.06^ab	197.99±1.29^a
ALT (U/L)	53.67±0.36^a	53.45±1.09^a	51.13±0.36^b	51.28±0.53^b	50.60±0.38^b	52.15±0.69^ab
ALP (U/L)	381.51±8.70	365.99±15.72	382.30±6.34	378.01±13.46	373.16±11.67	391.50±4.84
Cholesterol (mg/dL)	191.30±4.23^cd	184.25±5.18^d	206.58±4.69^b	201.13±5.15^bc	195.63±3.62^bc	221.65±4.27^a
Triglycerides (mg/dL)	186.48±3.31^c	181.95±5.76^c	204.40±5.98^b	219.98±3.93^a	223.73±3.91^a	224.29±5.38^a
HDL-chol (mg/dL)	150.2±1.62^ab	141.9±3.18^b	151.6±3.65^a	142.42±3.98^b	147.8±1.83^ab	150.68±1.11^ab

a,b,c,dMean values having different letters in column differ significantly (𝑃<0.05).