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| Herbal galactogogue | Proposed mechanism | Common doses and dosage form | Adverse Effects | Half-life |
|
Fenugreek
(Trigonella graecum foenum) | Estrogenic action? | Goat: dry plant 10 g SID [127] | Not reported. | Not reported. |
|
Fennel
(Foeniculum vulgare) | Estrogenic action? | Not reported | Not reported. | Not reported. |
|
Anise
(Pimpinella anisum) | Estrogenic action? | Rat: ethanolic and aqueous extract 1 g/kg IP [156] | Not reported. | Not reported. |
|
Goat’s rue
(Galega officinalis) | Estrogenic action? | Sheep: Plant (dry), 2 g/kg body weight in diet daily [158]. | Sheep: doses over 5 g/kg were toxic [161]. | Not reported. |
|
Asparagus
(Asparagus racemosus) | Estrogenic action? | Human: concentrated root extract, 60 mg/kg PO SID [166]. Rat: Plant (dry), 2% of the diet [167]. | Rat: methanol roots extract in dose of 100 mg/Kg/day for 60 days showed teratological disorders as increased resorption of fetuses, gross malformations as swelling in legs, and intrauterine growth retardation with a small placental size [171]. | Not reported. |
|
Milk thistle
(Silybum marianum) | Estrogenic action? | Bovine: plant (dry), 10 g PO SID [176]. | Human: gastrointestinal disturbances have been reported: nausea and diarrhea. Patients who have allergies to other members of the Asteraceae/Compositae plant family (including ragweed, marigolds, daisies, etc.) may exhibit allergic reactions to Milk Thistle derivatives [30]. | Human: silymarin elimination half-life average
6 hours [30]. |
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