Research Article

Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs

Table 1

Results from arterial blood gas analysis performed before the beginning of bleeding (1), at the end of the waiting period (2), in the end of the volume replacement (3), and in the end of the study one hour after the end of the volume replacement (4).

Before bleedingEnd of waiting End of volume replacementEnd of study
GLRGHESGLRGHESGLRGHESGLRGHES

PH7.45 ± 0.067.44 ± 0.037.4 ± 0.087.4 ± 0.08 7.5 ± 0.067.46 ± 0.04
PCO2 (mmHg)46.2 ± 5.847.5 ± 4.148.5 ± 6.948.9 ± 9.1 44.8 ± 5.645.9 ± 3.5
PO2 (mmHg)217.4 ± 73.9188 ± 48.8230.5 ± 62.0195.5 ± 38.0233.5 ± 49.9221.0 ± 65.0225.0 ± 40.9201.8 ± 50.6
NA+ (mEq/L)134.1 ± 5.1136 ± 2.0133.5 ± 4.8137.4 ± 2.2133.7 ± 5.0137.1 ± 1.3134.2 ± 5.0137.9 ± 1.64
K+ (mEq/L)5.8 ± 1.75.1 ± 1.25.3 ± 1.04.6 ± 0.735.13 ± 1.04.0 ± 0.54.9 ± 1.24.40 ± 0.52
CA++ (mg/dL)1.1 ± 0.221.2 ± 0.21.1 ± 0.11.1 ± 0.101.1 ± 0.040.98 ± 0.211.2 ± 0.31.18 ± 0.22
GLUC (mg/dL)60.9 ± 22.657.9 ± 13.563.3 ± 22.6 60.3 ± 28.281.5 ± 15.968.6 ± 27.868.3 ± 13.3
LACT (mmol/L)2.1 ± 1.12.0 ± 1.0 2.9 ± 0.7£1.7 ± 0.5£
HEMATOC (%)26.1 ± 4.626.4 ± 5.6 15.9 ± 1.1314.5 ± 2.118.2 ± 4.217.5 ± 3.5
(mEq/L)31.6 ± 2.532.4 ± 2.0 30.5 ± 1.430.0 ± 2.73
PT (g/dL)4.3 ± 0.84.1 ± 0.253.2 ± 0.6#2.78 ± 0.19#

GLR: group that received lactated Ringer’s for volume replacement; GHES: group that received hydroxyethyl starch for volume replacement. Mean ± standard deviation is shown. Significantly different from the previous measurement: , level. Significant differences between groups at the level. #Significant differences between the measurement “before bleeding” and the measurement “end of study.”