Effects of Acute Bleeding Followed by Hydroxyethyl Starch 130/0.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
Table 1
Results from arterial blood gas analysis performed before the beginning of bleeding (1), at the end of the waiting period (2), in the end of the volume replacement (3), and in the end of the study one hour after the end of the volume replacement (4).
Before bleeding
End of waiting
End of volume replacement
End of study
GLR
GHES
GLR
GHES
GLR
GHES
GLR
GHES
PH
7.45 ± 0.06
7.44 ± 0.03
7.4 ± 0.08
7.4 ± 0.08
7.5 ± 0.06
7.46 ± 0.04
PCO2 (mmHg)
46.2 ± 5.8
47.5 ± 4.1
48.5 ± 6.9
48.9 ± 9.1
44.8 ± 5.6
45.9 ± 3.5
PO2 (mmHg)
217.4 ± 73.9
188 ± 48.8
230.5 ± 62.0
195.5 ± 38.0
233.5 ± 49.9
221.0 ± 65.0
225.0 ± 40.9
201.8 ± 50.6
NA+ (mEq/L)
134.1 ± 5.1
136 ± 2.0
133.5 ± 4.8
137.4 ± 2.2
133.7 ± 5.0
137.1 ± 1.3
134.2 ± 5.0
137.9 ± 1.64
K+ (mEq/L)
5.8 ± 1.7
5.1 ± 1.2
5.3 ± 1.0
4.6 ± 0.73
5.13 ± 1.0
4.0 ± 0.5
4.9 ± 1.2
4.40 ± 0.52
CA++ (mg/dL)
1.1 ± 0.22
1.2 ± 0.2
1.1 ± 0.1
1.1 ± 0.10
1.1 ± 0.04
0.98 ± 0.21
1.2 ± 0.3
1.18 ± 0.22
GLUC (mg/dL)
60.9 ± 22.6
57.9 ± 13.5
63.3 ± 22.6
60.3 ± 28.2
81.5 ± 15.9
68.6 ± 27.8
68.3 ± 13.3
LACT (mmol/L)
2.1 ± 1.1
2.0 ± 1.0
2.9 ± 0.7£
1.7 ± 0.5£
HEMATOC (%)
26.1 ± 4.6
26.4 ± 5.6
15.9 ± 1.13
14.5 ± 2.1
18.2 ± 4.2
17.5 ± 3.5
(mEq/L)
31.6 ± 2.5
32.4 ± 2.0
30.5 ± 1.4
30.0 ± 2.73
PT (g/dL)
4.3 ± 0.8
4.1 ± 0.25
—
—
—
—
3.2 ± 0.6#
2.78 ± 0.19#
GLR: group that received lactated Ringer’s for volume replacement; GHES: group that received hydroxyethyl starch for volume replacement. Mean ± standard deviation is shown. Significantly different from the previous measurement: , level. Significant differences between groups at the level. #Significant differences between the measurement “before bleeding” and the measurement “end of study.”