Table 1: Pharmacokinetic parameters of levofloxacin in healthy and renal damaged ducks after a single IV administration of 10 mg kg−1 bwt ( ).

ParameterUnitHealthyRenal damaged

g mL−1
A g mL−1
B g mL−1
h−1
h−1
h−1
h−1
Ratio
h
h
VdssL kg−1
L kg−1h−1
AUC g mL−1h−1
AUMC g mL−1h−2
MRTh

, .
: concentration at zero time (immediately after single IV administration); A, B: zero-time intercepts of the biphasic disposition curve; , : hybrid rate constants representing the slopes of distribution and elimination phases, respectively; : first-order constant for transfer from central to peripheral compartment; : first-order constant for transfer from peripheral to central compartment; : distribution half-life; : elimination half-life; Vdss: volume of distribution at steady state; : total body clearance; AUC: area under serum concentration-time curve; AUMC: area under moment curve; MRT: mean residence time.