Table 1: Pharmacokinetic parameters of levofloxacin in healthy and renal damaged ducks after a single IV administration of 10 mg kg^{−1} bwt ().

Parameter

Unit

Healthy

Renal damaged

g mL^{−1}

A

g mL^{−1}

B

g mL^{−1}

h^{−1}

h^{−1}

h^{−1}

h^{−1}

Ratio

h

h

Vd_{ss}

L kg^{−1}

L kg^{−1}h^{−1}

AUC

g mL^{−1}h^{−1}

AUMC

g mL^{−1}h^{−2}

MRT

h

, . : concentration at zero time (immediately after single IV administration); A, B: zero-time intercepts of the biphasic disposition curve; , : hybrid rate constants representing the slopes of distribution and elimination phases, respectively; : first-order constant for transfer from central to peripheral compartment; : first-order constant for transfer from peripheral to central compartment; : distribution half-life; : elimination half-life; Vd_{ss}: volume of distribution at steady state; : total body clearance; AUC: area under serum concentration-time curve; AUMC: area under moment curve; MRT: mean residence time.