International Journal of Microbiology / 2012 / Article / Tab 2 / Review Article
Candida Biofilms and the Host: Models and New Concepts for EradicationTable 2 Candida biofilms in vivo models.
Models in vivo Device Developed in Catheter-associated models (i) Central venous system Rat [8 ], rabbit [64 ], mouse [65 ] (ii) Candiduria model Mouse [66 ] (iii) Subcutaneous foreign body system (biofilms developed after 2 to 6 days in infected implated catheter fragments) Rat (immunosuppressed before and during biofilm development) [9 ] Candida -associated denture stomatitis models(i) Acrylic denture material attached to the hard palate (biofilms developed between the hard palate and the device) Rat (immunosuppressed on day of infection) [67 ] (ii) Custom fitted denture system (cast fabrication of a fixed part that is attached to the posterior palate and a removable part fitted to the anterior palate) Rat [68 ] Mucosal model of oropharyngeal candidiasis Biofilms developed on the tongue after infection by swabbing and drinking water contaminated with Candida cells Mouse (immunosuppressed on day of infection) [12 ] Vaginitis model In vivo and ex vivo modelsMouse (treated with estradiol prior infection) [69 ]