Anastasis Stephanou serves as a Reader at University College London (UCL) and leads a group at the Medical Molecular Biology Unit. He completed his Ph.D. at the Westminster and Charring Cross Medical School, University of London, in 1992. He then did his postdoctoral training (1992-1995) at the Department of Endocrinology, Cincinnati Children’s Hospital, USA, working on transcriptional gene regulation. In 1995, he moved as a Postdoctoral Fellow to the laboratory led by Professor D. Latchman at the Windeyer Institute of medical Sciences, UCL, where he studied the regulation of heat shock proteins and their cytoprotective properties. During his postdoctoral work, he developed his interest in the signal transducers and activators of transcriptions (STATs) factors as key regulators of apoptosis. In 2002, he became a Lecturer at UCL, and in 2005, he was promoted to a Reader. His main research interests are opposing roles of STAT1 and STAT3 in regulating processes such as apoptosis, cell-cycle regulation, and autophagy in disease models such as cardiac ischaemia reperfusion injury and also in cancer. He has recently edited a book titled JAK-STAT Pathway in Diseases, and he has authored over 100 peer-reviewed articles. Other interests include collaborating with a colleague at the Mechanical Engineering Department at UCL, who has developed a novel technique called bioelectrospraying (BES) for deposition and controlled jetting of primary neonatal cardiac myocytes, primary cardiac cells, and endothelial cells, and both have created a beating cardiac tissue graft and are hoping to used such protocol for transplantation and treatment of severe heart failure models.
Biography Updated on 23 March 2011