Carolyn A. Staton

University of Sheffield, United Kingdom

Carolyn A. Staton undertook her Ph.D. studies in the role of fibrinogen and its related fragments on the process of tumor angiogenesis at the University of Sheffield, during which she discovered a number of novel antiangiogenic agents which were patented by the University of Sheffield and led to the funding of her postdoctoral research position to investigate these further. These studies led to her being given the AACR–Novartis Scholar In Training Award (2000) and the BACR Translational Research Award (2005)—both in open competition. She was appointed a Lectureship within the Microcirculation Research Group in the Academic Unit of Surgical Oncology at the University of Sheffield in 2004, and her research focus is on the regulation of angiogenesis, the development of new blood vessels from the preexisting vasculature, in wound healing and tumor development and progression. Angiogenesis and hemostasis, the coagulation cascade leading to clot formation, are among the most consistent host responses associated with cancer. Many haemostatic proteins stimulate angiogenesis by upregulating the expression of vascular endothelial growth factor (VEGF) and its receptors on endothelial cells. Other haemostatic proteins act directly on endothelial cells to inhibit or stimulate angiogenesis. Moreover, recently proteins originally identified as important in neuronal guidance are now suspected to be involved in regulating angiogenesis, both positively and negatively. Thus, her research aims to establish a comprehensive understanding of the relationships between these important processes, both in physiological conditions and the manner in which this changes during cancer development as this has implications for cancer therapy. Staton also has a strong interest in the development and refinement of assays used to study angiogenesis and as such was an Executive Editor on a book entitled Angiogenesis Assays: a Critical Appraisal of Current Techniques published by John Wiley & Sons.

Biography Updated on 7 September 2011

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