Kusuki Nishioka

St. Marianna University School of Medicine, Japan

Kusuki Nishioka is a Professor of medicine at the Research Institute of Medical Center at St. Marianna University, Japan. His potential activities for scientific, educational, and social achievements in the field of rheumatology were as follows. He has focused on the pathogenesis of rheumatoid arthritis especially hyperplasia of synoviocytes and/or macrophage following bone and joint destruction and on the role of human T cell leukemia virus- (HTLV-1-) associated arthropathy with immune dysregulation. He clearly demonstrated a role of transregulatory role of HTLV-1 tax gene contributing both induction of synovial hyperplasia and immune dysregulation, either in vitro and transgenic mice. Second novel finding is the presence of Fas-mediated apoptosis rheumatoid synovial tissue either in vivo or in vitro. This finding is potentially important for understanding pathogenesis and treatment for RA. He developed agonistic protein which induced apoptosis in RA synovium and established a novel concept for the treatment of RA. He has proposed immunological intervention in the pathogenesis of OA. This finding strongly suggests the presence of autoimmunity in the pathophysiology of OA, and this concept leads to novel development for treatment of OA. In addition to scientific activity, he has been established a lot of educational program for young rheumatologist. He has taken over 26 years or more as a Professor and the Director of the Rheumatology Department of the institute. During teaching position, he has been taking care of many Japanese young research fellows and other Asian Pacific Area. He has established educational and research program for foreign countries fellows in his institute.

Biography Updated on 24 March 2010

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