David K. Simon

Beth Israel Deaconess Medical Center, USA


David K. Simon completed his undergraduate training at Johns Hopkins University in 1986, and then earned an M.S. and Ph.D. degrees (in neuroscience) at Washington University in St. Louis in 1993. He then completed a neurology residency in the Harvard Longwood Neurology Residency Training Program, followed by a movement disorders fellowship at Massachusetts General Hospital. Subsequently, he joined the faculty at Beth Israel Deaconess Medical Center and Harvard Medical School, where he is now an Associate Professor of neurology. His laboratory studies the impact of somatic mtDNA mutations in the brain in aging and in age-related neurodegenerative disorders, particularly Parkinson’s disease (PD). His laboratory also has investigated PGC-1a, a master regulator of mitochondrial biogenesis and antioxidant activities, as a neuroprotective target in aging and in PD, as well as its potential role in the neuroprotective effects of physical exercise. Dr. Simon is Cochair of the Parkinson Study Group Genetics and Environmental Risk Factors working group, periodically reviews grants for the Michael J. Fox foundation, and is serving a 4-year term as a member of the NIH Molecular Neurogenetics (MNG) study section. Dr. Simon also currently is the Cochair of the PSG Scientific Review Committee, and is on the Steering Committee of the NET-PD futility study of pioglitazone as a potential neuroprotective agent in PD. Dr. Simon’s areas of expertise include movement disorders (especially PD), mitochondrial disorders, mitochondrial genetics and somatic mitochondrial DNA mutations, and neuroprotection.

Biography Updated on 23 May 2012

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