Patrick Legembre

Universite de Rennes-1, France


After a Ph.D. degree obtained in 2002 from the University of Bordeaux 2, Bordeaux, France, Patrick Legembre started his Postdoctoral training at the Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, USA, in the Laboratory of Professor Marcus Peter, where he studied the nonapoptotic signals triggered by the death receptor CD95 (Fas/Apo1). As a Principal Investigator (2005 to 2009) in the Laboratory of Professor Jean-Fran&#xE7ois Moreau (University of Bordeaux-2, France), he showed that the redistribution of CD95 into lipid rafts promoted the initial steps of apoptotic signaling pathway. In 2010, he created his team entitled “Death Receptors and Tumor Escape” at the University of Rennes 1 (Inserm U1085, IRSET). Since then, he has demonstrated that in contrast to membrane-bound CD95L, metalloprotease-cleaved CD95L (cl-CD95L) participated in the progression of lupus disease by promoting accumulation of activated T lymphocytes in damaged organs. In addition, his laboratory observed that in the presence of cl-CD95L, CD95 elicited the formation of a molecular complex that he called MISC, for motility-inducing signaling complex, which ultimately implemented a nonorthodox c-yes/Orai1/Ca2+/PI3K signaling pathway. More recently, he dissected the rapid and transient antiapoptotic role of Ca2+ in the initial steps of CD95 signaling. Overall, these findings revisit the role of CD95 as a death receptor and bring to light its participation in promoting chronic inflammatory disorders.

Biography Updated on 1 June 2013

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