Jose L. Garcia Perez

Universidad de Granada, Spain

I received my Ph.D. in Molecular Biology from the University of Granada-Spanish Research Council (CSIC) in 2003, where I studied under Dr. Manuel Carlos Lopez the mobilization of repeated DNA in Trypanosomes. In late 2003, I joined the University of Michigan Medical School (Department of Human Genetics, Lab of Dr. John V. Moran) as a post-doctoral fellow. In 2007, I was promoted to Research Investigator in the University of Michigan, and since late 2008 I am a Group Leader in Spain. My lab is currently located at Genyo within the Department of Human DNA Variability, Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain). In January 2012, the Howard Hughes Medical Institute appointed me as an International Early Career Scientist. I have worked in the field of transposable elements for more than 10 years and have published over 30 articles (the total includes articles, reviews, book chapters, perspectives, and a thesis). More than 40% of the human genome is composed of repeated DNA, and some types can be mobilized within the genome (e.g., Transposable Elements (TE)). As a result, the human genome is not static, and poses some degree of plasticity. Long Interspersed Element-1 (LINE-1 or L1) is the only autonomous retrotransposon (a class of TEs) in the human genome. Overall, L1 is responsible for a third of the human genome. Its mobility has resulted in a variety of human diseases, and its activity has shaped the human genome during evolution. Despite their abundance, little is known about human cell types that can accommodate the mobility of such repeated DNA sequences. Our lab studies the impact and control of L1s in the human genome.

Biography Updated on 19 June 2012

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