Terrence C. Town

Cedars-Sinai, USA

Terrence Town holds a Ph.D. degree. He is a research scientist at the Department of Biomedical Science and the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center. He holds the Ben Winters Chair in Regenerative Medicine. Prior to joining Cedars-Sinai, Dr. Town was an Associate Research Scientist at the Department of Immunology at Yale University/Howard Hughes Medical Institute in Connecticut. His research focuses on molecular genetics, cellular and molecular biology, and pathology and imaging. His work has shown that key immune molecules play central roles in the pathoetiology of neurodegenerative diseases such as Alzheimer's disease, encephalitis, stroke, and multiple sclerosis. Dr. Town uses genetically modified mice (transgenics and knock-outs) programmed to develop these diseases. The mice are used as preclinical models to conduct laboratory studies aimed at targeting neuroimmune molecules for eventual therapeutic intervention. His work relies heavily on cutting-edge imaging analysis of brain pathology and cellular/molecular biological techniques to accomplish this goal. He is the inventor of methods and compounds for disruption of CD40/CD40L signaling in the treatment of Alzheimer's disease, method and assay for diagnosing substance dependency, CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease, modulation of the phospholipase A2 pathway as a therapeutic, inhibition of Alzheimer's beta-amyloid-induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism, and methods and compositions for stimulating CD45 and thereby suppressing microglial activation associated with Alzheimer's disease.

Biography Updated on 3 November 2011

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